Mahendra and Olivier were sollicited by Valérie Daugé at MICALIS institute to analyze feces microbiota (V3-V4 regions of the 16S rDNA gene): α- and β-diversities and differential abundance analyses of OTUs.
In conclusion, the probiotic mixture tested (M) can beneficially affect anxiety- and depressive-like behaviors in both naturally stress-sensitive Fischer rats and maternally deprived Long Evans rats. M modified the composition of the gut microbiota, intestinal physiology in Fischer and Long Evans rats and brain monoamines in Fischer rats. intestinal tight junction protein expression and some cecal and serum levels of certain metabolites in Fischer and Long Evans rats were observed, reinforcing our knowledge of the links between the gut microbiota and the brain. The next step will be to investigate the behavioral effects of methylthioadenosine, thymidine, 2-acetamido-2-deoxy-beta-D-glucosylamine and 21-deoxycortisol in our experimental models and to determine their mechanisms of action.
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